Endocrine Abstracts

Giant cell tumors are rare, benign but aggressive and locally invasive tumors that usually affect the long bones in the limbs, typically presenting during the 3rd or 4th decade of life. Giant cell tumors of the skull are exceedingly rare, and less than 150 cases have been reported to date, of which less than 10 were described in the pediatric population. Here, we present the case of a 14 year old female that progressively developed severe headaches, blurr...

Background: Primary thyroid angiosarcoma (PTA), previously considered a vascular type of anaplastic thyroid carcinoma (ATC), is a rare, aggressive malignant mesenchymal tumor, with a peak incidence in the seventh decade of life. PTA can present as an ATC, a more frequent type of thyroid malignancy. Differential diagnosis is of major importance, as the management and prognosis differ significantly.Case report: A 72-year-old woman presented for a 2 month h...

One of the clinical complications associated with the long term use of bisphosphonates treatment in osteoporosis is the atypical femoral fracture (AFF).Even the absolute risk is low and acceptable compared with the number of fractures prevented, there are still reasonable concerns due to the wide prescription of bisphosphonates and the existence of several case series proving that bisphosphonates have a strong association with this unique fracture type. We present a case of a ...

Parathyroid carcinoma (PC) rarely presents with metastasis at diagnosis and usually in patients also having gross local invasion.Case presentation: We report the case of a 51-year-old postmenopausal woman presenting at our institution in June 2019 with symptomatic hypercalcemia (fatigue, polyuria, constipation and bone pain), but with a surprisingly good general condition. She had been treated with bisphosphonates for osteoporosis (DXA: LS T score &#8722...

The secretion of adipocytokines is influenced by fat mass, but also by various situations related to acute stress (food deprivation, or critical state related to inflamatory or infectious syndromes). Adipocytokinic secretory profile could be therefore used for the diagnosis of the type of critical state, as well for the evolution and survival prognosis of patients. The modifications of adipocytokinic markers during the first hours after surgical intervention are insufficiently...

Transsphenoidal surgery still appears to be the best option for most of the patients with GH secreting adenomas. In many cases the biochemical cure targets are not reached and the patient needs adjuvant therapy. Alternatives include medical therapy with somatostatin analogues, GH-receptor antagonists and dopamine agonists. These drugs can be used alone or in combination. Radiation therapy with conventional fractionated photons or radiosurgery with proton beam could also be eff...

Introduction: Somatostatin analogs, formerly used as adjuvants in acromegaly treatment, are widely used as primary treatment today.Objective: To investigate the efficacy of octreotide therapy in acromegalic patients as primary or secondary therapy.Materials and methods: Four acromegalic patients diagnosed at the Endocrinological Clinic (males, mean age 35–75 years, age range 26–49 years, all patients with macroadenoma) we...

Introduction: Bisphosphonates therapy is the standard of care in postmenopausal osteoporosis. In the HORIZON-RFT, annual i.v. Zoledronic acid (ZOL) 5 mg infusion significantly reduced the rate of new fractures by increased bone mineral density (BMD). We proposed to evaluate the effect of ZOL treatment in BMD change in a group of postmenopausal osteoporotic women assessed by DXA–BMD. We have proposed also to assess the adverse events of this treatment.<p class="abstext...

Introduction: Prolactinomas are rare in childhood and adolescence, representing a half of pituitary adenomas (1% of intracranial tumors); macroadenomas are more frequent than microadenomas. The signs and symptoms depend on age, sex, tumor size and prolactin level. Due to a higher frequency of macroadenomas in boys, they present more often neuro-ophthalmologic findings (impaired vision, headache)Case report: We present a case of 25-year-old pacient diagno...

Prolactinomas represent 60% of primary pituitary tumors, galactorrrhoea and menstrual disturbances beeing the most frequent clinical features in women. The mass effect of macroadenomas is expressed by headache, visual field defects and hypopituitarism. The aims of therapy are reduction of tumour size, prevention of tumour expansion and restoration of gonadal function. Dopamine agonists normalize prolactin secretion and reduce tumour size in 40% of patients with macroadenoma.</...